Prurigo nodularis - प्रुरिगो नोडुलरिस
☆ जर्मनीबाट 2022 Stiftung Warentest नतिजाहरूमा, ModelDerm सँग उपभोक्ता सन्तुष्टि सशुल्क टेलिमेडिसिन परामर्शको तुलनामा थोरै मात्र थियो।
References
Prurigo nodularis लामो समयसम्म चल्ने छालाको अवस्था हो जुन धेरै फर्म बम्पहरू र नोडलहरू द्वारा विशेषता हुन्छ, सामान्यतया हात र खुट्टाको बाहिरी भागहरूमा पाइन्छ। यी बम्पहरू मासु-टोन्ड देखि गुलाबी रंगमा भिन्न हुन सक्छन् र तीव्र रूपमा चिलाउने हुन्छन्। तिनीहरूले कुनै पनि उमेरका मानिसहरूलाई असर गर्न सक्छन् र प्रायः अन्य छाला अवस्थाहरूसँग जोडिएको हुन्छ जसले पुरानो खुजलीको कारण बनाउँछ, जस्तै एटोपिक डर्मेटाइटिस। उपचार विकल्पहरूमा बलियो चिलाउने औषधिहरू, प्रतिरक्षा प्रणालीलाई असर गर्ने औषधिहरू, र स्नायु प्रणालीलाई लक्षित गर्ने औषधिहरू समावेश छन्। prurigo nodularis को प्रबन्ध गर्न सामान्यतया दीर्घकालीन उपचार समावेश छ।
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
उपचारमा सामान्यतया प्रभावित क्षेत्रमा क्रिम वा स्टेरोइडको इन्जेक्सन प्रयोग गरिन्छ। अधिक गम्भीर वा जिद्दी अवस्थामा, हल्का थेरापी वा प्रतिरक्षा प्रणालीलाई दबाइने औषधिहरू जस्ता उपचारहरू आवश्यक हुन सक्छ। थालिडोमाइड र लेनालिडोमाइड गम्भीर अवस्थाका लागि विकल्पहरू हुन्, तर तिनीहरूको गम्भीर साइड इफेक्ट हुन सक्छ। नयाँ उपचार (opioid receptor antagonists, neurokinin-1 receptor antagonists) ले थालिडोमाइड वा लेनालिडोमाइडको तुलनामा कम साइड इफेक्टको साथ प्रुरिगो नोड्युलरिसको उपचारमा प्रतिज्ञा देखाउँदछ।
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo एक छालाको अवस्था हो जुन लामो समयसम्म चिलाउने (६ हप्ताभन्दा लामो समयसम्म) , स्क्र्याच-सम्बन्धित छालाको घाउ, र बारम्बार खरोंचको इतिहास हो। यसले छालामा न्यूरोइन्फ्लेमेशन र फाइब्रोसिस समावेश गर्दछ।
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis चिलाउने नोड्युलहरू द्वारा चिन्हित एक लामो समयसम्म छाला समस्या हो। हामीलाई यो के कारणले ठ्याक्कै थाहा छैन, तर यस्तो देखिन्छ कि प्रतिरक्षा र स्नायु समस्याहरूले खुजली-स्क्र्याच चक्रमा भूमिका खेल्छ। अहिले, US FDA द्वारा विशेष गरी prurigo nodularis को लागि अनुमोदित कुनै पनि उपचार छैन।
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ उपचार - ओटीसी ड्रग्स
घाउ भएको क्षेत्रलाई साबुनले धुनुले कुनै पनि फाइदा गर्दैन र यसलाई अझ खराब बनाउन सक्छ। OTC स्टेरोइड मलमले लक्षणहरू कम गर्न मद्दत गर्न सक्छ, तर तिनीहरू सामान्यतया सुधार गर्न धेरै हप्तासम्म लागू गर्न आवश्यक छ। एन्टिहिस्टामाइन्स सेवन जारी राख्दा पनि चिलाउने समस्याबाट मुक्ति मिल्छ।
#OTC steroid ointment
#OTC antihistamine
○ उपचार
#Intralesional triamcinolone injection